80194-70-3
- Product Name：3-chloro-2-cyano-5-trifluoromethylpyridine
- Molecular Formula：C7H2ClF3N2
- Purity：99%
- Molecular Weight：206.554
Product Details
Purity:99%
Manufacturer supply good quality 3-chloro-2-cyano-5-trifluoromethylpyridine 80194-70-3 with stock
- Molecular Formula:C7H2ClF3N2
- Molecular Weight:206.554
- Vapor Pressure:0.0218mmHg at 25°C
- Refractive Index:1.482
- Boiling Point:250.4 °C at 760 mmHg
- PKA:-5.03±0.20(Predicted)
- Flash Point:105.2 °C
- PSA：36.68000
- Density:1.51 g/cm3
- LogP:2.62548
2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine(Cas 80194-70-3) Usage
|
General Description |
2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine, also known as CTFP, is a chemical compound with the formula C7H2ClF3N2. It is a pyridine derivative that contains a cyano, chloro, and trifluoromethyl group. CTFP is a highly versatile building block in organic synthesis, used for the production of various pharmaceuticals, agrochemicals, and materials. It has been employed in the synthesis of novel heterocyclic compounds with potential biological activities. CTFP is also used as an intermediate in the manufacturing of active pharmaceutical ingredients and is frequently employed in research and development laboratories for its unique chemical properties. Additionally, it is important to handle CTFP with caution as it is flammable and may cause skin and eye irritation. |
InChI:InChI=1/C7H2ClF3N2/c8-5-1-4(7(9,10)11)3-13-6(5)2-12/h1,3H
80194-70-3 Relevant articles
Combined preparation method of 2-cyano-3-chloro-5-trifluoromethylpyridine and succinonitrile
-
Paragraph 0024-0036, (2021/02/24)
The invention discloses a combined prepa...
3-chloro-2-cyano-5-trifluoromethyl pyridine preparation method
-
Paragraph 0026, (2017/04/28)
The invention discloses a 3-chloro-2-cya...
3 - chloro -5 - trifluoromethyl pyridine compounds and intermediates method (by machine translation)
-
Paragraph 0086; 0087; 0088; 0089; 0090; 0091; 0092-0094, (2017/07/20)
The invention discloses a 3 - chloro -5 ...
A 2 - cyano - 3 - chloro - 5 - trifluoro methyl pyridine synthesis method (by machine translation)
-
Paragraph 0032; 0034, (2017/11/04)
The invention discloses a 2 - cyano - 3 ...
80194-70-3 Process route
-
-
80194-70-3
3-chloro-2-cyano-5-(trifluoromethyl)pyridine
-
-
69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
| Conditions | Yield |
|---|---|
|
|
|
|
|
-
-
773837-37-9
sodium cyanide
-
-
72537-17-8
2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
-
-
80194-70-3
3-chloro-2-cyano-5-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
2-fluoro-3-chloro-5-(trifluoromethyl)pyridine;
With
dmap;
In
acetone;
for 5h;
Reflux;
Large scale;
sodium cyanide;
In
chloroform; water;
at 20 ℃;
for 2.5h;
Large scale;
|
89% |
|
dmap;
In
water; propiononitrile;
at 20 ℃;
for 5h;
|
83% |
|
With
tetrabutylammomium bromide;
In
water; dimethyl sulfoxide;
at 45 - 50 ℃;
Concentration;
|
74.3% |
|
With
N-benzyl-N,N,N-triethylammonium chloride;
at 20 ℃;
for 10h;
Temperature;
|
46.7 g |
80194-70-3 Upstream products
-
72537-17-8
2-fluoro-3-chloro-5-(trifluoromethyl)pyridine
-
69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
-
773837-37-9
sodium cyanide
-
10442-39-4
tetra-n-butylammonium cyanide
80194-70-3 Downstream products
-
175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
-
164341-39-3
(5-(trifluoromethyl)pyridin-2-yl)methanamine
-
80194-71-4
3-fluoro-5-(trifluoromethyl)picolinonitrile
-
80194-68-9
3-chloro-5-trifluoromethylpyridine-2-carboxylic acid
Relevant Products
-
Ethyl 3-chloro-5-trifluoromethylpyridine-2-carboxylateCAS：128073-16-5
-
Methyl 3-hydroxy-2-pyridinecarboxylateCAS：62733-99-7
-
2-cyanoisonicotinic acid ethyl esterCAS：58481-14-4
