59146-67-7
- Product Name：2-Cyano-5,6-dimethylpyridine
- Molecular Formula：C8H8N2
- Purity：99%
- Molecular Weight：132.16
Product Details
Purity:99%
Purity 99% Min 2-Cyano-5,6-dimethylpyridine 59146-67-7 Spot Supply with Safe Transportation
- Molecular Formula:C8H8N2
- Molecular Weight:132.16
- Boiling Point:280.7±35.0 °C(Predicted)
- PKA:0.69±0.10(Predicted)
- PSA：36.68000
- Density:1.05±0.1 g/cm3(Predicted)
- LogP:1.57008
59146-67-7 Relevant articles
SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS
-
Page/Page column 57, (2014/09/29)
The present invention is directed to sub...
SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS
-
Page/Page column 57, (2014/10/04)
The present invention is directed to sub...
5-lipoxygenase-activating protein (FLAP) inhibitors. Part 4: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin- 2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor
Stock, Nicholas S.,Bain, Gretchen,Zunic, Jasmine,Li, Yiwei,Ziff, Jeannie,Roppe, Jeffrey,Santini, Angelina,Darlington, Janice,Prodanovich, Pat,King, Christopher D.,Baccei, Christopher,Lee, Catherine,Rong, Haojing,Chapman, Charles,Broadhead, Alex,Lorrain, Dan,Correa, Lucia,Hutchinson, John H.,Evans, Jilly F.,Prasit, Peppi
experimental part, p. 8013 - 8029 (2012/03/08)
The potent 5-lipoxygenase-activating pro...
BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS
-
Page/Page column 63; 64, (2011/02/24)
The present invention relates to benzoxa...
59146-67-7 Process route
-
-
22710-07-2,166521-76-2
2,3-dimethylpyridine 1-oxide
-
-
7677-24-9
trimethylsilyl cyanide
-
-
59146-67-7
5,6-dimethylpyridine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
With
N,N-Dimethylcarbamoyl chloride;
In
dichloromethane;
at 20 ℃;
for 72h;
|
75% |
|
With
N,N-diethylcarbamyl chloride;
In
dichloromethane;
at 20 ℃;
for 60h;
Inert atmosphere;
|
53% |
|
With
N,N-diethylcarbamyl chloride;
In
1,2-dichloro-ethane;
Ambient temperature;
|
|
|
2,3-dimethylpyridine 1-oxide; trimethylsilyl cyanide;
With
triethylamine;
In
acetonitrile;
at 90 ℃;
for 120h;
Inert atmosphere;
With
sodium hydroxide;
In
water; acetonitrile;
at 0 ℃;
|
|
|
2,3-dimethylpyridine 1-oxide; trimethylsilyl cyanide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
N,N-diethylcarbamyl chloride;
In
dichloromethane;
at 20 ℃;
for 24h;
|
|
|
2,3-dimethylpyridine 1-oxide; trimethylsilyl cyanide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
N,N-diethylcarbamyl chloride;
In
dichloromethane;
for 24h;
|
-
aq. K2 CO3
-
aq. K2 CO3
-
-
60-29-7,927820-24-4
diethyl ether
-
-
7677-24-9
trimethylsilyl cyanide
-
-
88-10-8
N,N-diethylcarbamyl chloride
-
-
59146-67-7
5,6-dimethylpyridine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
In
dichloromethane;
|
59146-67-7 Upstream products
-
22710-07-2
2,3-dimethylpyridine 1-oxide
-
7677-24-9
trimethylsilyl cyanide
-
60-29-7
diethyl ether
-
88-10-8
N,N-diethylcarbamyl chloride
59146-67-7 Downstream products
-
543713-56-0
(5,6-dimethylpyridin-2-yl)methanamine
-
153646-65-2
2-hydroxymethyl-5,6-dimethylpyridine
-
83282-49-9
5,6-dimethyl-pyridine-2-carboxylic acid
Relevant Products
-
Methyl ortho hydroxy para aminobenzoateCAS：4136-97-4
-
8-Hydroxyquinoline-2-carboxylic acidCAS：6759-78-0
-
Cyclopropaneacetic acidCAS：5239-82-7
