321601-48-3
- Product Name：Methyl 6-bromo-3-hydroxy-2-pyridinecarboxylate
- Molecular Formula：C7H6BrNO3
- Purity：99%
- Molecular Weight：232.034
Product Details
Purity:99%
Reliable Quality Methyl 6-bromo-3-hydroxy-2-pyridinecarboxylate 321601-48-3 Hot Sale with Chinese Manufacturer
- Molecular Formula:C7H6BrNO3
- Molecular Weight:232.034
- Boiling Point:388.8±37.0 °C(Predicted)
- PKA:3.49±0.10(Predicted)
- PSA：59.42000
- Density:1.716±0.06 g/cm3(Predicted)
- LogP:1.33630
321601-48-3 Relevant articles
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase
Thalji, Reema K.,Raha, Kaushik,Andreotti, Daniele,Checchia, Anna,Cui, Haifeng,Meneghelli, Giovanni,Profeta, Roberto,Tonelli, Federica,Tommasi, Simona,Bakshi, Tania,Donovan, Brian T.,Howells, Alison,Jain, Shruti,Nixon, Christopher,Quinque, Geoffrey,McCloskey, Lynn,Bax, Benjamin D.,Neu, Margarete,Chan, Pan F.,Stavenger, Robert A.
, p. 1407 - 1412 (2019)
A series of DNA gyrase inhibitors were d...
CARBALDEHYDE OXIMES AS BUTYRYLCHOLINESTERASE REACTIVATORS
-
Paragraph 0086; 0101-0102, (2022/02/07)
The present invention relates to compoun...
Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2
Nguyen, William,Lee, Erinna F.,Evangelista, Marco,Lee, Mihwa,Harris, Tiffany J.,Colman, Peter M.,Smith, Nicholas A.,Williams, Luke B.,Jarman, Kate E.,Lowes, Kym N.,Haeberli, Cécile,Keiser, Jennifer,Smith, Brian J.,Fairlie, W. Douglas,Sleebs, Brad E.
, p. 1143 - 1163 (2021/02/22)
Limited therapeutic options are availabl...
HPK1 ANTAGONISTS AND USES THEREOF
-
Paragraph 1014; 1016, (2021/03/19)
The present invention provides compounds...
SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR
-
Paragraph 0434; 0436, (2020/08/16)
Provided is a sulfonyl-substituted bicyc...
321601-48-3 Process route
-
-
62733-99-7
methyl 3-hydroxypicolinate
-
-
321601-48-3
methyl 6-bromo-3-hydroxypyridine-2-carboxylate
| Conditions | Yield |
|---|---|
|
With
bromine;
In
water;
at 0 ℃;
regioselective reaction;
|
99% |
|
With
bromine;
In
water;
at 0 ℃;
|
99% |
|
With
bromine;
In
water;
at 0 ℃;
|
99% |
|
With
bromine;
In
water;
at 20 ℃;
for 3h;
|
82% |
|
With
bromine;
In
water;
at 25 ℃;
|
80.7% |
|
With
bromine;
In
water;
at 20 ℃;
|
80.7% |
|
With
bromine;
In
water;
at 25 ℃;
|
80.7% |
|
With
bromine;
In
water;
at 20 ℃;
for 3h;
|
80% |
|
With
bromine;
In
water;
|
79% |
|
With
bromine;
In
water;
at 20 ℃;
for 4h;
|
74% |
|
With
bromine;
In
water;
at 20 ℃;
for 4h;
|
72% |
|
With
bromine;
In
water;
at 20 ℃;
for 2h;
|
66% |
|
With
bromine;
In
water;
at 0 - 20 ℃;
for 17h;
|
53% |
|
With
bromine;
In
water;
at 0 - 20 ℃;
for 17h;
|
53% |
|
With
bromine;
In
water;
at 0 ℃;
for 2h;
|
52.8% |
|
With
bromine;
In
water;
|
|
|
With
bromine;
In
water;
at 20 ℃;
|
|
|
With
bromine;
In
water;
for 0.5h;
|
|
|
With
bromine;
In
water;
at 20 ℃;
for 3h;
|
|
|
With
bromine;
In
water;
at 20 ℃;
for 6h;
|
3.5 g |
-
-
874-24-8
3-hydroxypyridine-2-carboxylic acid
-
-
321601-48-3
methyl 6-bromo-3-hydroxypyridine-2-carboxylate
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 24 h / Reflux
2: bromine / water / 17 h / 0 - 20 °C
With
sulfuric acid; bromine;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 80 °C
2: bromine / water / 25 °C
With
sulfuric acid; bromine;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 24 h / 0 °C / Reflux
2: bromine / water / 4 h / 20 °C
With
sulfuric acid; bromine;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 6 h / 0 °C / Reflux
2: bromine / water / 0 °C
With
sulfuric acid; bromine;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 72 h / 70 °C / Inert atmosphere
2: bromine / water / 2 h / 20 °C
With
sulfuric acid; bromine;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / methanol / 16 h / 0 - 80 °C
2: bromine / water / 6 h / 20 °C
With
sulfuric acid; bromine;
In
methanol; water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 72 h / 20 °C / Reflux
2: bromine / water / 3 h / 20 °C
With
sulfuric acid; bromine;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sulfuric acid / 6 h / 0 °C / Reflux
2: bromine / water / 0 °C
With
sulfuric acid; bromine;
In
water;
|
321601-48-3 Upstream products
-
62733-99-7
methyl 3-hydroxypicolinate
-
874-24-8
3-hydroxypyridine-2-carboxylic acid
-
67-56-1
methanol
321601-48-3 Downstream products
-
945954-94-9
methyl 6-bromo-3-methoxypyridine-2-carboxylate
-
1135872-25-1
6-bromo-3-(3-phenoxy-propoxy)-pyridine-2-carboxylic acid methyl ester
-
1310031-62-9
methyl 3-(benzyloxy)-6-(5-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)pent-1-ynyl)picolinate
-
1310031-64-1
methyl 6-(5-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)pentyl)-3-hydroxypicolinate
Relevant Products
-
3-bromo-4-nitropyridine oxideCAS：1678-49-5
-
1,3-PhenylenediacetonitrileCAS：626-22-2
-
Isonicotinic acid-N-oxideCAS：13602-12-5
