38275-57-9
- Product Name：2-cyano-5-bromopyrimidine
- Molecular Formula：C5H2BrN3
- Purity：99%
- Molecular Weight：183.995
Product Details
Purity:99%
Factory Supply industrial standard 2-cyano-5-bromopyrimidine 38275-57-9 In Stock
- Molecular Formula:C5H2BrN3
- Molecular Weight:183.995
- Vapor Pressure:0.000379mmHg at 25°C
- Refractive Index:1.617
- Boiling Point:317.7 °C at 760 mmHg
- PKA:-4.65±0.22(Predicted)
- Flash Point:145.9 °C
- PSA：49.57000
- Density:1.86g/cm3
- LogP:1.11078
5-Bromopyrimidine-2-carbonitrile(Cas 38275-57-9) Usage
InChI:InChI=1/C5H2BrN3/c6-4-2-8-5(1-7)9-3-4/h2-3H
38275-57-9 Relevant articles
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility
Zak, Mark,Liederer, Bianca M.,Sampath, Deepak,Yuen, Po-Wai,Bair, Kenneth W.,Baumeister, Timm,Buckmelter, Alexandre J.,Clodfelter, Karl H.,Cheng, Eric,Crocker, Lisa,Fu, Bang,Han, Bingsong,Li, Guangkun,Ho, Yen-Ching,Lin, Jian,Liu, Xiongcai,Ly, Justin,O'Brien, Thomas,Reynolds, Dominic J.,Skelton, Nicholas,Smith, Chase C.,Tay, Suzanne,Wang, Weiru,Wang, Zhongguo,Xiao, Yang,Zhang, Lei,Zhao, Guiling,Zheng, Xiaozhang,Dragovich, Peter S.
, p. 529 - 541 (2015/03/05)
Herein we report the optimization effort...
Cyclic Amines
-
Paragraph 0170; 0171, (2014/05/07)
The present invention is directed to nov...
Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA Desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome
Zhang, Zaihui,Sun, Shaoyi,Kodumuru, Vishnumurthy,Hou, Duanjie,Liu, Shifeng,Chakka, Nagasree,Sviridov, Serguei,Chowdhury, Sultan,McLaren, David G.,Ratkay, Leslie G.,Khakh, Kuldip,Cheng, Xing,Gschwend, Heinz W.,Kamboj, Rajender,Fu, Jianmin,Winther, Michael D.
, p. 568 - 583 (2013/04/23)
Stearoyl-CoA desaturase-1 (SCD1) catalyz...
PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES
-
Page/Page column 98, (2013/09/12)
Disclosed are certain pyridinyl and pyri...
38275-57-9 Process route
-
-
7677-24-9
trimethylsilyl cyanide
-
-
36529-69-8
5-bromopyrimidine N-oxide
-
-
114969-66-3
5-bromo-4-cyanopyrimidine
-
-
38275-57-9
5-bromopyrimidine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
acetonitrile;
for 0.5h;
Yields of byproduct given;
Ambient temperature;
|
22% |
-
-
143-33-9,25596-52-5
sodium cyanide
-
-
32779-36-5
5-Bromo-2-chloropyrimidine
-
-
38275-57-9
5-bromopyrimidine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
With
1,4-diaza-bicyclo[2.2.2]octane;
In
water; dimethyl sulfoxide;
at 20 ℃;
for 18h;
|
99% |
|
1,4-diaza-bicyclo[2.2.2]octane;
In
water; dimethyl sulfoxide;
at 20 ℃;
|
88% |
|
With
1,4-diaza-bicyclo[2.2.2]octane;
In
water; dimethyl sulfoxide;
at 20 ℃;
for 2h;
|
|
|
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 18h;
|
38275-57-9 Upstream products
-
7677-24-9
trimethylsilyl cyanide
-
36529-69-8
5-bromopyrimidine N-oxide
-
143-33-9
sodium cyanide
-
32779-36-5
5-Bromo-2-chloropyrimidine
38275-57-9 Downstream products
-
1068975-23-4
(5-bromo-pyrimidine-2-yl)-phenyl-methanone
-
951657-88-8
1,4-bis-(2'-cyanopyrimidin-5'-yl)-phenylene
-
951658-05-2
5-(4'-bromophenyl)-2-pyrimidinecarbonitrile
-
1189169-37-6
1-(5-bromopyrimidin-2-yl)ethan-1-one
Relevant Products
-
3-bromo-6-methylpyridine-2-carboxylic acidCAS：717843-48-6
-
2-Cyano-5-chloropyrimidineCAS：38275-56-8
-
2-Carboxylic acid-3-bromopyridineCAS：30683-23-9
