135048-32-7
- Product Name：2-cyanoisoniazid
- Molecular Formula：C7H6N4O
- Purity：99%
- Molecular Weight：162.151
Product Details
Purity:99%
Factory Supply Industrial Grade 2-cyanoisoniazid 135048-32-7 with Best Price
- Molecular Formula:C7H6N4O
- Molecular Weight:162.151
- PKA:10.38±0.10(Predicted)
- PSA：91.80000
- Density:1.37±0.1 g/cm3(Predicted)
- LogP:0.64798
135048-32-7 Relevant articles
Preparation method of medicine for treating chronic hyperuricemia
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Paragraph 0013; 0025; 0026; 0031; 0032; 0037; 0038; 0043, (2021/04/14)
The invention discloses a preparation me...
Preparation method of topiroxostat intermediate
-
Paragraph 0029-0034; 0047-0055, (2020/02/14)
The invention discloses a preparation me...
Preparation method of topiroxostat
-
Paragraph 0028; 0029; 0030; 0031; 0047; 0049; 0050-0063, (2018/03/26)
The invention provides a preparation met...
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Paragraph 0065-0074, (2018/03/26)
The invention relates to a preparation m...
135048-32-7 Process route
-
-
94413-64-6
2-Cyano-4-carbomethoxypyridine
-
-
135048-32-7
2-cyanoisonicotinic acid hydrazide
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrochloride;
In
ethanol;
at 0 ℃;
for 2.5h;
Temperature;
Solvent;
Reagent/catalyst;
|
96.3% |
|
With
hydrazine hydrate;
In
ethanol;
at -15 ℃;
for 3h;
Temperature;
|
84.3% |
|
With
hydrazine hydrate;
In
ethanol;
at 80 ℃;
for 5h;
|
|
|
2-Cyano-4-carbomethoxypyridine;
With
hydrazine;
In
methanol;
for 2h;
In
chloroform;
at 20 ℃;
for 1h;
|
|
|
With
hydrazine hydrate;
In
methanol;
at 25 - 35 ℃;
for 6h;
Temperature;
|
|
|
With
hydrazine hydrate;
In
ethanol;
at 25 - 35 ℃;
for 2h;
Large scale;
|
14.3 kg |
-
-
161233-97-2
2-cyanopyridine-4-carboxylic acid
-
-
135048-32-7
2-cyanoisonicotinic acid hydrazide
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrate; O-phenyl phosphorodichloridate; N-ethyl-N,N-diisopropylamine;
In
chloroform;
at 20 ℃;
for 48h;
Concentration;
Reagent/catalyst;
Temperature;
Solvent;
|
94.6% |
|
2-cyanopyridine-4-carboxylic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
hydrazine;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
|
135048-32-7 Upstream products
-
94413-64-6
2-Cyano-4-carbomethoxypyridine
-
161233-97-2
2-cyanopyridine-4-carboxylic acid
-
3783-38-8
methyl isonicotinate N-oxide
-
58481-14-4
2-cyano-isonicotinic acid ethyl ester
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